4-氨基四氢吡喃的一锅法合成工艺

Abstract

本发明公开了一种4-氨基四氢吡喃的一锅法合成工艺,以4-氰基四氢吡喃、氢氧化钠溶液(或氢氧化钾溶液)为原料合成4-甲酰胺四氢吡喃,再往4-甲酰胺四氢吡喃中缓慢加入次氯酸钠溶液(或次溴酸钠溶液),随后加热升温至回流,脱羧生成产物4-氨基四氢吡喃。将所有反应原料放在一锅中反应,通过选择合适的反应条件,合成4-氨基四氢吡喃,选择性高,杂质少,中间产物不用分离,收率高,实用价值高。

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